stillingsbetegnelse:
PhD position in Protein Intermolecular Interactions within the EU ITN project PIPPI (ESR3)

jobbeskrivelse:
A 3-year PhD scholarship in structural biology is available at Novozymes A/S and Department of Chemistry, Technical University of Denmark. The position will be available from 1st of June 2016 or as soon as possible thereafter. The PhD student will be part of the EU-funded project “Protein-excipient Interactions and Protein-Protein Interactions in formulations” (PIPPI). Apart from the research work itself, the students’ participation in the project will involve tight collaboration with project partners and frequent visits to the involved labs, active participation at the bi-annual network events, as well as training in complementary skills such as project management. About PIPPI PIPPI is an Innovative Training Network (ITN) concerning the challenges in formulation of protein-based drugs. PIPPI will combine systematic investigations of the physicochemical behavior of a number of proteins with an in-depth understanding of the molecular interactions behind the macroscopic behavior. The overall objective is to develop methodologies, tools and databases to guide the formulation of robust biopharmaceuticals in the future. The Technical University of Denmark (DK) coordinates this exciting collaborative project. The academic partners include University of Manchester (UK), Ludwig-Maximilian University, Munich (DE), Lund University (SE), University of Copenhagen (DK), MAXIV Laboratory (SE). The industry partners involved in the project include: Novozymes A/S (DK), MedImmune Ltd. (UK), Wyatt Technology Europe GmbH (DE), NanoTemper Technologies GmbH (DE). Each of the project partners contributes world-class competence in particular areas. The core research contribution of DTU Chemistry is in the area of Structural and Computational Biology and comprises X-ray scattering and computer modeling techniques to study structure-function relationship of proteins and protein-protein complexes. The core research contribution from Novozymes is in the area of protein stability and aggregation, protein formulation and protein purification. This PhD project (ESR3) will work on the molecular basis for protein-protein interactions from measurements of static structure factors for proteins that are available at high protein concentrations. The molecular basis for protein-protein interactions is poorly understood due to their transient nature and inability of interaction models to capture experimental behaviour. The intermolecular solution structure of proteins is the controlling factor in determining the formulation attributes. Protein-protein interactions will studied under multiple conditions using static and dynamic light scattering techniques. Small-Angle X-ray Scattering studies will be performed to determine the structure factor and thereby the nature of the inter-molecular interactions. The experiments will be supplemented by in-silico modelling to elucidate the nature of protein-protein interactions in concentrated solution structure. Secondment The successful candidate will visit both academic and industrial partners during the project. This will ensure the buildup of a portfolio of interdisciplinary techniques relevant for the applicant’s project and PIPPI objectives. Qualifications Applicants should hold a Master of Science degree in Chemistry, Biochemistry, Biotechnology, pharmaceutical science, chemical engineering or an equivalent background that provides a strong set of analytical skills. The applicant should have a strong interest in working in a cross-disciplinary environment and should have very good collaboration skills. Strong communication skills and a strong academic record is an advantage. Fluent communication skills in written and spoken English are essential. The applicant should strive towards scientific excellence, be ambitious and hard working. Only applicants with great talent, which seeks to be among the brightest in their field, will be considered. Approval and Enrolment The scholarships for the PhD degree are subject

Arbejdsgiver Navn: Danmarks Tekniske Universitet

Arbejdsgiver telefonnummer: 45252525

Arbejdsgiver faxnummer: 45881799

Job kort beskrivelse:
Undervisning og forskning på universiteter og højere læreranstalter

land: Danmark

region: Hovedstaden

krævede uddannelse: Ikke angivet

Kilde til jobtilbud: AMS, Offentlige arbejdsformidlinger, Danmark