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reference: 4943049

documentId: 4943049

connectionPointId: 7

lastModificationDate: 1549620196670

stillingsbetegnelse:
Postdoc in Biomaterials-based Approach for the Creation of Artificial Red Blood Cells

jobbeskrivelse:

A postdoctoral position is available at the Biomimetics, Biocarriers and Bioimplants group (The 3Bs) headed by Assoc. Prof. Leticia Hosta-Rigau, DTU Health Tech, Technical University of Denmark, Kgs. Lyngby, Denmark.

The 3Bs is a highly interdisciplinary and positive group with open-minded and supportive members. The 3Bs research lies on the interface of materials science, organic/polymer chemistry together with molecular and cell biology. The research focus areas of the group are drug delivery, tissue engineering and cell mimicry.

The 3Bs are well embedded into the Biopharma division, where multiple young research groups work closely together to create a motivating environment.

With this announced position, we will assemble a haemoglobin-based oxygen carrier to be used when donor blood is not an option or not available.

The position is available as soon as possible.

Responsibilities and tasks

Blood is crucial for our survival and the only way to substitute for blood loss occurring during accidents or surgery is by using blood from donors. However, blood transfusions have some limitations and risks: before blood can be transfused, there is a need for typing and matching due to the different blood groups causing fatal delays in emergency situations. Also, blood has a short storage lifetime, which makes it impossible to create large blood supplies to be used in acute disasters such as earthquakes or plane accidents. Furthermore, blood transfusions can help spreading new viral infections, like it happened with HIV in the 80s. Thus, developing a new oxygen-carrier solution for use when red blood cells are neither an option or available persists as one of the foremost important challenges in biomedicine.

The successful candidate will work in a highly interdisciplinary project in the interface of polymer chemistry, materials science together with molecular and cell biology.

The research project will be focused in the fabrication of a new class of microcarriers with potential to serve as substitutes for red blood cells.

The successful candidate will be responsible to:

• Assemble hemoglobin-loaded polymeric carriers
• Conduct a thorough characterization of the system by means of several techniques (e.g., optical and electron microscopy, flow cytometry, DLS)
• Assess their biocompatibility and potential cell uptake by several relevant cell lines
• Conduct an in vivo characterization in murine models

Qualifications

The successful applicant should hold a PhD degree in polymer chemistry, materials science, pharmacy or similar and has a general overview of how to fabricate and characterize drug delivery systems.

Preference will be given to candidates that:

• Have a strong background in colloids and interfaces and polymer chemistry
• Have experience on analytical techniques (optical and electron microscopy (TEM, SEM), flow cytometry, fluorescence spectroscopy, HPLC, dynamic light scattering, zeta-potential measurements, etc.)
• Have experience in mammalian cell culture (cell viability assays, cell internalization, cell imaging etc.)
• Have experience with murine models (biodistribution, histological examination etc.)
• Demonstrate a strong profile for research documented through original publications in peer-reviewed scientific journals

We offer

DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment

The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The initial contract will be for one year.

You can read more about career paths at DTU here. http://www.dtu.dk/english/about/job-and-career/working-at-dtu/career-paths

Further information

Further information may be obtained from Associate Professor Leticia Hosta-Rigau, leri (at) dtu.dk.

You can read more about DTU Health Tech on http://www.healthtech.dtu.dk.

Application procedure

Please submit your online application no later than 1 March 2019 (local time). To apply, please open the link "Apply online", fill out the online application form. The following must be attached in English:

• Application (cover letter)
• CV
• Diploma (MSc/PhD)
• List of publications

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

The DTU Health Technology Department located at the so-called 'Medicon Valley', is an international-class research platform where around 300 researchers work together to provide new technology and new solutions to improve the quality of patient care and public health and well-being.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.


numberOfPosts: 1

jobCategoriesCodes_0: http://data.europa.eu/esco/isco/C2310

abstractJV_contact_0: Please apply using one of the specified channels

positionTypeCode: directhire

contractTypeCodes_0: fulltime

Arbejdsgiver Navn: Danmarks Tekniske Universitet

source: DK-STAR