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stillingsbetegnelse: PhD scholarship in Optical Microscopy

jobbeskrivelse:

The Department of Electrical Engineering invite applications for a 3-year PhD position on developing and applying new optical microscopy techniques to map how the intestine absorbs biopharmaceuticals.

The PhD Student will be part of the Biomedical Engineering Group and will interface closely with the Novo Nordisk-sponsored Centre for Intestinal Absorption and Transport of Biopharmaceuticals, which is characterized by its interdisciplinary research strategy.

Currently, our efforts on microscope development are anchored in the Biomedical Engineering Group (which will host the initial phase of this position). Yet, this whole research group and the Centre for Intestinal Absorption and Transport of Biopharmaceuticals will soon move to DTU's new Department of Health Technology. This transition represents an exciting opportunity for us (and for you as a PhD Student) to reinvent our research strategies as well as our approaches to teaching and learning.

The PhD Student will be responsible for constructing a 'light sheet' fluorescence microscope for live-sample imaging of 3D printed organoids mimicking the intestinal barrier. In close collaboration with biologists and image analysts at DTU and internationally, the PhD Student will use this microscope to pursue a deeper understanding of how biopharmaceuticals and other compounds pass from the intestinal lumen to the blood. The successful team effort will provide new insights, which will advance our means to treat disease as well as our general understanding of biological life.

Responsibilities and tasks

The PhD Student will play a central role in our mission to understand intestinal absorption at the molecular level and be responsible for implementing one of the Worlds most advanced optical microscopes for live-sample imaging - an effort, which will require some initial training (approx. 3 months) in our collaborators' labs in the United States. Likely, the project will involve additional trips to the United States as microscope implementation at DTU progresses.

At DTU, the PhD Student will use the microscope together with local biologist and image analysts to capture how fluorescently labelled biopharmaceuticals travel through the intestinal barrier. During this application-oriented phase of the project, the PhD Student will be responsible for optimizing microscope hardware and software to provide the best images possible.

The PhD Student's ability to drive hardware/software development will be essential. Likewise, also have the ability to document, present, and publish scientific findings will be central.

Finally, it is important that the PhD Student is motivated to contribute to the enjoyable and collaborative work environment in DTU's new Department of Health Technology, which will host our research group and research centre starting January 1st 2019.

Qualifications

Candidates should have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree.

The ideal candidate for the scholarship can:

• Work independently and prioritize tasks with team-success in mind.
• Plan and execute complex hardware implementation, i.e. interface optics, electronics, and software.
• Work constructively in a team of diverse scientist, i.e. analyse and contribute to solve biological/mathematical challenges.
• Use software for instrument control, e.g. LabVIEW.
• Use software for data simulation and basic image analysis, e.g. MATLAB.
• Use software for basic mechanical design, e.g. SOLIDWORKS.
• Communicate professionally and fluently in English (also in writing).
• Present insights, progress, and bottlenecks to diverse (non-expert) audiences, including: Local/international collaborators, BSc/MSc students, and the public.
• Enjoy science and adhere to the European code of conduct for research integrity.

Previous training with an emphasis on software/hardware development and some exposure to fundamental biology/physiology is preferable.

Approval and Enrolment

The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the DTU PhD Guide. http://www.dtu.dk/english/Education/PhD/Rules/PhDguide

Assessment

The assessment of applicants will be made by Associate Professor Emil B. Kromann (main advisor), Professor Niels B. Larsen (co-advisor) and Professor Jens E. Wilhjelm (co-advisor).

We offer

DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and appointment terms

The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.

The work place will be at DTU Lyngby Campus. Additionally, the PhD Fellow will work/study abroad for short periods.

You can read more about career paths at DTU here. http://www.dtu.dk/english/about/job-and-career/working-at-dtu/career-paths

Further information

Further information may be obtained from Associate Professor Emil B. Kromann, ebkro (at) dtu.dk, +45 4525 3682.

You can read more about the Department of Electrical Engineering at http://www.elektro.dtu.dk.

Application

Please submit your online application no later than 15 January 2019 (local time). To apply, please open the link "Apply online", fill out the online application form. The following must be attached in English:

• A letter motivating the application (cover letter)
• Curriculum vitae
• Grade transcripts and BSc/MSc diploma
• Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here) http://www.dtu.dk/english/Education/phd/Applicant/Pre_acceptance-1-

Candidates may apply prior to obtaining their master's degree but cannot begin before having received it.

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

The Department of Electrical Engineering is the central department within electrical and biomedical engineering. It is our goal to ensure research and engineering training at the highest international level. The department is organized into eight groups each covering important areas of electrical and biomedical engineering. Including PhD students we have more than 270 staff members.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.


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jobCategoriesCodes_0: http://data.europa.eu/esco/isco/C2310

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positionTypeCode: directhire

contractTypeCodes_0: fulltime

Arbejdsgiver Navn: Danmarks Tekniske Universitet

source: DK-STAR