stillingsbetegnelse:
PhD position in Pharmaceutical Technology within the EU ITN project PIPPI (ESR8)

jobbeskrivelse:
A 3-year PhD scholarship in pharmaceutical technology is available at Wyatt Technology Europe GmbH, Germany. The position will be available from 1st of June 2016 or as soon as possible thereafter. The PhD student will be part of the EU-funded project “Protein-excipient Interactions and Protein-Protein Interactions in formulations” (PIPPI). Apart from the research work itself, the students’ participation in the project will involve tight collaboration with project partners and frequent visits to the involved labs, active participation at the bi-annual network events, as well as training in complementary skills such as project management. About PIPPI PIPPI is an Innovative Training Network (ITN) concerning the challenges in formulation of protein-based drugs. PIPPI will combine systematic investigations of the physicochemical behavior of a number of proteins with an in-depth understanding of the molecular interactions behind the macroscopic behavior. The overall objective is to develop methodologies, tools and databases to guide the formulation of robust biopharmaceuticals in the future. The Technical University of Denmark (DK) coordinates this exciting collaborative project. The academic partners include University of Manchester (UK), Ludwig-Maximilian University, Munich (DE), Lund University (SE), University of Copenhagen (DK), MAXIV Laboratory (SE). The industry partners involved in the project include: Novozymes A/S (DK), MedImmune Ltd. (UK), Wyatt Technology Europe GmbH (DE), NanoTemper Technologies GmbH (DE). Each of the project partners contributes world-class competence in particular areas. Wyatt Technology is a distributor of a range of analytical instruments for macromolecular and particle characterization, specifically for protein characterization. Method development and customization of characterization procedures is a core competence of Wyatt Technology. The aim of this PhD project is to develop a toolkit for predicting protein aggregation. Aggregation involves multiple pathways with various rate controlling steps. This includes the formation of small populations of partially folded molecules, which are difficult to isolate and study as well as the protein-protein-interactions. From this a full spectrum of protein aggregates of different evolves. These aspects need to be studied over time to understand individual kinetics. This PhD project approaches the problem by establishing and applying automated methods for quantifying aggregation kinetics by time-resolved fluorescence, static and dynamic light scattering and special size exclusion chromatography - multi angle laser light scattering setups with modified sampling systems. Furthermore, the more complex asymmetrical flow field flow fractionation and raster image correlation spectroscopy will provide additional details about time-evolution of monomer and oligomer species. Together with other PhD students of this consortium the first systematic study of aggregation kinetics for a database of proteins in a range of formulation conditions will be performed. Secondment The successful candidate will visit both academic and industrial partners during the project. This will ensure the buildup of a portfolio of interdisciplinary techniques relevant for the applicant’s project and PIPPI objectives. Qualifications Applicants should hold a Master of Science degree in Chemistry, Biochemistry, Biotechnology, Pharmaceutical Science, Chemical Engineering or an equivalent background that provides a strong set of analytical skills. The applicant should have a strong interest in working in a cross-disciplinary environment and should have very good collaboration skills. Strong communication skills and a strong academic record is an advantage. Fluent communication skills in written and spoken English are essential. The applicant should strive towards scientific excellence, be ambitious and hard working. Only applicants with great talent, which seek to be among the brightest in

Arbejdsgiver Navn: Danmarks Tekniske Universitet

Arbejdsgiver telefonnummer: 45252525

Arbejdsgiver faxnummer: 45881799

Job kort beskrivelse:
Undervisning og forskning på universiteter og højere læreranstalter

land: Danmark

region: Hovedstaden

krævede uddannelse: Ikke angivet

Kilde til jobtilbud: AMS, Offentlige arbejdsformidlinger, Danmark