stillingsbetegnelse:
PhD position in Computational Biology within the EU ITN project PIPPI (ESR2)

jobbeskrivelse:
3-year PhD scholarship in Computational Biology: Molecular Modelling and Bioinformatics is available at Department of Chemistry, Technical University of Denmark. The position will be available from 1st of June 2016 or as soon as possible thereafter. The PhD student will be part of the EU-funded project “Protein-excipient Interactions and Protein-Protein Interactions in formulations” (PIPPI). Apart from the research work itself, the students’ participation in the project will involve tight collaboration with project partners and frequent visits to the involved labs, active participation at the bi-annual network events, as well as training in complementary skills such as project management. About PIPPI PIPPI is an Innovative Training Network (ITN) concerning the challenges in formulation of protein-based drugs. PIPPI will combine systematic investigations of the physicochemical behavior of a number of proteins with an in-depth understanding of the molecular interactions behind the macroscopic behavior. The overall objective is to develop methodologies, tools and databases to guide the formulation of robust biopharmaceuticals in the future. The Technical University of Denmark (DK) coordinates this exciting collaborative project. The academic partners include University of Manchester (UK), Ludwig-Maximilian University, Munich (DE), Lund University (SE), University of Copenhagen (DK), MAXIV Laboratory (SE). The industry partners involved in the project include: Novozymes A/S (DK), MedImmune Ltd. (UK), Wyatt Technology Europe GmbH (DE), NanoTemper Technologies GmbH (DE). Each of the project partners contributes world-class competence in particular areas. The core research contribution of DTU Chemistry is in the area of Structural and Computational Biology and comprises X-ray scattering and computer modeling techniques to study structure-function relationship of proteins and protein-protein complexes. The current PhD project focuses on the determination of protein-excipients interaction sites (‘hot spots’) at different physicochemical conditions such as pH and ionic strength using computer simulation techniques. Currently, a detailed molecular understanding of the effect of different physicochemical formulation conditions and the addition of excipients on the stability of proteins and protein complexes are sparse. This is mainly due to the fact that molecular interactions on molecular level are difficult to probe experimentally. Here, bioinformatics tools, molecular docking and molecular dynamics simulations will be used to study the effect of excipients on protein stability and to identify excipient hot spot regions on proteins and protein-protein complexes with the aim to correlate these results with experimentally determined structural and stability data generated in the consortium. Secondment The successful candidate will visit both academic and industrial partners during the project. This will ensure the buildup of a portfolio of interdisciplinary techniques relevant for the applicant’s project and PIPPI objectives. Qualifications Applicants should hold a Master of Science degree in Chemistry, Biochemistry, Biotechnology, Pharmaceutical Science, Chemical Engineering or an equivalent background that provides a strong basis of computational techniques and analytical skills. The applicant should have a strong interest in working in a cross-disciplinary environment and should have very good collaboration skills. Strong communication skills and a strong academic record is an advantage. Fluent communication skills in written and spoken English are essential. The applicant should strive towards scientific excellence, be ambitious and hard working. Only applicants with great talent, which seeks to be among the brightest in their field, will be considered. Approval and Enrolment The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of

Arbejdsgiver Navn: Danmarks Tekniske Universitet

Arbejdsgiver telefonnummer: 45252525

Arbejdsgiver faxnummer: 45881799

Job kort beskrivelse:
Undervisning og forskning på universiteter og højere læreranstalter

land: Danmark

region: Hovedstaden

krævede uddannelse: Ikke angivet

Kilde til jobtilbud: AMS, Offentlige arbejdsformidlinger, Danmark